T-shaped uterus in diethylstilbestrol (DES) exposure
نویسندگان
چکیده
منابع مشابه
Diethylstilbestrol (DES) in the US
Diethylstilbestrol (DES) is an artificially created hormone [4] first synthesized in the late 1930s. Doctors widely prescribed DES first to pregnant women to prevent miscarriages, and later as an emergency contraceptive pill and to treat breast cancer. However, in 1971, physicians showed a link between DES and vaginal cancer during puberty in the children of women who had taken DES while pregna...
متن کاملDevelopmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus.
Alteration of DNA demethylation in five CpG sites (-547, -533, -475, -464, and -454) immediately upstream from the estrogen response element of lactoferrin promoter was determined in the uteri of immature (17-day-old) and mature (21- and 30-day-old) mice treated neonatally with DES. Only the CpG/-464 was found to be abnormally demethylated by diethylstilbestrol (DES) treatment in the mature ute...
متن کاملMorphological effects of diethylstilbestrol on neonatal mouse uterus and vagina.
Administration of diethylstilbestrol (DES) to neonatal mice causes a high incidence of vaginal adenosis comparable to adenosis in women who were exposed to DES in utero. In the present study, scanning electron microscopy was used to investigate morphological events that might be involved in the development of adenosis. The effects of DES on luminal epithelia of neonatal mouse uterus, vaginal ca...
متن کاملNeonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus.
Perinatal exposure to diethylstilbestrol (DES) induces reproductive tract cancers later in life in both humans and animals. Because there is no clear evidence that perinatal DES exposure induces gene mutation, we proposed that perinatal DES exposure causes epigenetic methylation changes that result in persistent alterations in gene expression, leading to tumorigenesis. The proto-oncogene c-fos ...
متن کاملNeonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouse uterus.
Perinatal exposure to diethylstilbestrol (DES) can have numerous adverse effects on the reproductive organs later in life, such as vaginal clear-cell adenocarcinoma. Epigenetic processes including DNA methylation may be involved in the mechanisms. We subcutaneously injected DES to neonatal C57BL/6 mice. At days 5, 14, and 30, expressions of DNA methyltransferases (Dnmts) Dnmt1, Dnmt3a, and Dnmt...
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ژورنال
عنوان ژورنال: American Journal of Roentgenology
سال: 1979
ISSN: 0361-803X,1546-3141
DOI: 10.2214/ajr.132.6.979